DIFFUSE PULMONARY OSSIFICATION (DPO): AN INFREQUENT FORM OF INTERSTITIAL LUNG DISEASE

Diffuse pulmonary interstitial disease; an immunohistologic study.

Extensive diffuse pulmonary ossification.

Diffuse lung injury can either heal normally or progress to fibrosis. Calcification in the setting of fibrosis is common. The appearance of mature woven bone is not. We report a patient with extensive diffuse pulmonary ossification and discuss some of the theories relating to the development of this phenomenon.

Idiopathic diffuse pulmonary ossification.

A 51 year old man presented with a 1 year history of fatigue and night sweats, cough with clear sputum, central chest discomfort, and mild exertional dys-pnoea. A detailed exposure history was negative. Laboratory investigations including tuberculin skin test, white cell count, ESR, C-reactive protein, urea, creatinine and electrolytes, protein electrophoresis, rheumatoid factor, antinuclear an...

Ask the expert - diffuse interstitial lung disease

HRCT is now a key diagnostic tool in diffuse lung disease, but has not completely replaced histopathological diagnosis. In many cases, HRCT can provide disease-specific information so biopsy can be avoided when the clinical presentation is characteristic [1]. This is relevant for some rarer interstitial lung diseases, such as lymphangioleiomyomatosis (LAM; multiple uniform thin-walled cysts; di...

Carcinoma of the lung and diffuse interstitial pulmonary fibrosis.

The clinical and histopathological findings are presented in two cases of diffuse interstitial pulmonary fibrosis in which carcinoma of the lung developed. In one case with rheumatoid arthritis and diffuse interstitial pulmonary fibrosis there was ;malignant pulmonary adenomatosis', an association which does not appear to have been reported before. In the second case idiopathic diffuse intersti...